COVID-19 是冠状动脉疾病风险等价物,并与 ABO 血型具有遗传相互作用

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James R Hilser^1,2, Neal J Spencer^1,2, Kimia Afshari^1,2

¹Department of Population and Public Health Sciences (J.R.H., N.J.S., K.A., F.D.G., H.H., J.A.H., H.A.), Keck School of Medicine, University of Southern California, Los Angeles.

Arteriosclerosis, thrombosis, and vascular biology

|October 9, 2024

概括

住院治疗COVID-19显著增加长期重大心脏不良事件 (MACE) 的风险,作为冠状动脉疾病风险等价物. 非O型血型在COVID-19后面临高血栓事件的风险,这表明基因与病原体的相互作用.

科学领域:

心血管医学心血管医学
传染性疾病传染性疾病
遗传学遗传学是一个

背景情况:

COVID-19 (冠状病毒疾病2019) 与主要心脏不良事件 (MACE) 的风险增加有关,包括心脏病发作,中风和死亡.
长期心血管疾病 (CVD) 风险和COVID-19感染后的MACE决定因素仍然不清楚.

研究的目的:

评估COVID-19感染后MACE的长期风险.
为了确定COVID-19住院是否相当于冠状动脉疾病 (CAD) 的风险.
研究MACE发育中的遗传因素和COVID-19之间的潜在相互作用.

主要方法:

利用了2020年2月1日至2020年12月31日的英国生物银行数据.
通过PCR测试或ICD-10代码识别的COVID-19病例 (n=10,005).
使用比例危险模型和倾向得分匹配的对照 (n=38,860) 来分析长期MACE风险 (>1000天).

主要成果:

在所有严重程度的COVID-19病例中,MACE风险增加 (HR 2.09),在住院病例中显著增加 (HR 3.85).
住院治疗COVID-19是CAD风险等价,非心血管疾病患者的MACE风险高于没有COVID-19的心血管疾病患者 (HR 1.21).
在ABO血型位点和COVID-19住院治疗之间发现了显著的相互作用 (P=0.01),增加了非O血型的血栓事件风险 (HR 1.65).

结论:

住院治疗COVID-19相当于CAD风险等价,观察到急性心肌梗塞和中风风险增加.
非O型血型在COVID-19住院治疗后,患血栓事件的风险特别高.
这项研究提出了第一个被记录的基因-病原体相互作用影响血栓事件之一.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.遗传学遗传学遗传学是一个主要的不良心脏事件.心肌梗塞的心脏病发作一次性中风中风中风中风中风血栓形成的原因是血栓形成.

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