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Updated: Jun 11, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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微RNA触发可编程DNA编码的PROTACs,用于细胞选择性和受控的蛋白质降解

Jiayin Zhan1,2, Xiang Li1, Zhe Feng1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China.

Angewandte Chemie (International ed. in English)
|October 9, 2024
PubMed
概括

我们开发了一种新的miRNA启动组装前PROTAC (miRiaTAC) 平台,用于按需降解蛋白质. 这项技术提供了增强的瘤选择性和受控的癌症治疗,改进了现有的蛋白质溶解向化马.

关键词:
DNA 组装 DNA 组装这是一个微型RNA.光学规则 光学规则这就是PROTAC.时间空间控制控制

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