唐氏综合征儿童和青少年上呼吸道刺激:长期随访
Danielle R Larrow1, Kathryn S Marcus1, Kevin Gipson2,3
1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, Massachusetts, U.S.A.
The Laryngoscope
|October 9, 2024
概括
低分泌神经刺激 (HGNS) 改善了唐氏综合征 (DS) 青少年的阻塞性睡眠呼吸暂停 (OSA). 长期随访显示,睡眠呼吸暂停参数持续有好处,这表明HGNS是一种可行的治疗选择.
科学领域:
- 睡眠医学 睡眠医学
- 神经学 神经学
- 遗传学 是一个遗传学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是患有唐氏综合征 (DS) 的青少年的重大健康问题.
- 低分泌神经刺激 (HGNS) 已被证明是一个有前途的治疗严重的OSA.
- 在患有OSA的DS患者中,HGNS的长期疗效仍然被低估.
研究的目的:
- 评估HGNS在患有唐氏综合征和严重持久性OSA的青少年患者的长期结果.
- 在延长的随访期内评估HGNS在多睡眠图 (PSG) 参数上的持续疗效.
主要方法:
- 一个前性的,单组的,多中心的队列研究.
- 包括42名患有DS和严重持久性OSA的青少年患者.
- 在基线,植入后1年和长期随访 (平均4.0年) 中评估了PSG患者.
主要成果:
- 有33名患者的长期随访数据.
- 治疗响应率 (≥50%的AHI降低) 在1年内为69.7%,长期增加到87.9%.
- 平均呼吸暂停-呼吸暂停指数 (AHI) 在1年 (-51.1%) 和长期随访 (-59.6%) 均显著下降.
结论:
- HGNS植入可以导致持续改善PSG参数的青少年与DS和严重的OSA.
- 对于这一群体来说,HGNS似乎是一种安全有效的长期治疗选择.
- 需要进一步的研究来探索其他长期结果,如神经认知和生活质量.
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