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静脉注射与下甲松对患者短期反应的影响:一项随机对照试验
Ellen P Pearce1, David E Deas1, Charles A Powell1
1Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA.
下甲松有效地减少了经过牙周手术后的疼痛和胀,类似于静脉注射. 这种方法特别有用,当静脉输入不需要镇静时.
科学领域:
- 牙周手术 牙周手术
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 手术后的疼痛和胀在牙周叶片手术后很常见.
- 德克萨米他是一种用于减轻炎症和疼痛的皮质类固醇.
- 为了优化患者的治疗结果,比较静脉注射 (IV) 和下注射途径至关重要.
研究的目的:
- 为了比较粘膜下和IV德克萨米他在减少牙周皮手术后疼痛,胀和止痛药消耗方面的疗效.
- 评估两种施用途径之间观察到的任何差异的临床相关性.
主要方法:
- 一个随机的交叉试验,涉及39名接受牙周皮手术的患者.
- 患者通过静脉注射或粘膜下途径接受8毫克德克萨梅他,安慰剂通过交叉设计的替代途径给予.
- 疼痛,胀和止痛药的使用被记录在术后168小时使用数值和视觉评分尺度.
主要成果:
- 在静脉和下甲松之间,没有发现疼痛水平或止痛药消耗的显著差异.
- 在72小时后输入静脉注射后 (p=0.047),观察到统计学意义上的胀减少,尽管其临床相关性有限.
- 这两种施用途径在治疗术后症状方面表现出相似的疗效.
结论:
- 在经过牙周皮手术后,下甲和IV甲在控制疼痛和止痛药的使用方面同样有效.
- 下注射提供了一个可行的替代方案,特别是当静止不需要IV接入时.
- 这些发现支持使用下甲松在牙周手术中有效减轻疼痛.
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