牙周炎和糖尿病对肥胖症的炎症有不同的影响
S SantaCruz-Calvo1,2, S Saraswat2, H Hasturk3
1Department of Pharmacology & Nutritional Sciences, Lexington, KY, USA.
Journal of dental research
|October 9, 2024
概括
牙周炎 (PD) 在肥胖和2型糖尿病 (T2D) 中对全身炎症的影响不同. 了解这些独特的口腔代谢联系对于治疗相关炎症性疾病至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 口腔健康 口腔健康
- 代谢疾病 代谢疾病
背景情况:
- 牙周炎 (PD) 加剧全身炎症,特别是在肥胖和2型糖尿病 (T2D) 中.
- 以前的研究经常将肥胖和T2D归类,掩盖了PD对其炎症概况的明显影响.
研究的目的:
- 研究PD如何影响人类肥胖和T2D中的细胞因子产生.
- 为了区分PD在肥胖中的炎症影响与T2D.
主要方法:
- 从患有不同疾病的受试者收集的外周血液单核细胞 (PBMC).
- 在刺激T细胞和骨髓状细胞后,使用Bioplex检测测试验量化细胞因子分泌.
- 使用部分最小平方差分分析分析数据.
主要成果:
- 在肥胖患者中,PD显著改变了T细胞和骨髓质炎症.
- 在T2D中,PD会影响骨髓质,但不会影响T细胞炎症.
- 在PD和T2D之间观察到双向的炎症关系.
- 在T2D患者中,晚期PD (第四阶段) 与早期阶段相比,显示T细胞和髓质细胞因子产量减少.
结论:
- PD和T2D通过重叠但在肥胖中不同的途径影响系统性炎症.
- 评估口腔健康 (PD阶段) 和代谢状态对于了解PD的全身影响至关重要.
- 考虑多个细胞细胞因子来源对于临床管理PD的系统影响至关重要.
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