在纯虚弱和肥胖虚弱中重叠和明显的物理和生物现象
Fujue Ji1,2, Ji Hyun Park1, Hyeonseung Rheem1,2
1Major in Sport Science, Division of Sport Industry and Science, College of Performing Arts and Sport, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea.
Bioscience reports
|October 9, 2024
概括
纯虚弱和肥胖虚弱表现出明显的身体特征,但共享重叠的生物学表型,特别是在肌肉蛋白质合成调节方面. 肥胖会加剧肥胖者的身体障碍.
科学领域:
- 老年学是指老年学的学科.
- 代谢障碍 代谢障碍 代谢障碍
- 肌肉生理学 肌肉生理学
背景情况:
- 虚弱综合征呈现为纯虚弱和肥胖的虚弱.
- 这些脆弱类型之间的重叠和独特特征尚未得到很好的定义.
- 了解这些差异对于有针对性的干预至关重要.
研究的目的:
- 阐明纯虚弱和肥胖虚弱的重叠和明显的物理和生物现象.
- 为改善预防,诊断和治疗策略提供基础.
- 在肥胖的背景下区分脆弱的表现.
主要方法:
- 使用小鼠模型,养正常或高脂肪饮食,并在20个月后进行评估.
- 组包括对照,肥胖,纯虚弱和肥胖的虚弱.
- 评估了关键的身体参数 (握力,步行速度,活动,耐力,体重) 和生物标志物.
主要成果:
- 在体重,瘦肉/脂肪量,握力,耐力和活动水平之间,在纯虚弱和肥胖之间,注意到了不同的身体现象.
- 步行速度是一个共享的物理现象型.
- 生物表现型在Smad2/3,FoxO3a,P62,LAMP-2和cathepsin L中显示出明显的表达,而AKT,mTOR,p-Smad2/3,p-FoxO3a,Beclin-1,ATG7和LC3重叠.
结论:
- 肥胖脆弱的独特的身体现象主要源于肥胖,加上脆弱.
- 纯和肥胖的脆弱性共享共同的生物学表型,特别是在肌肉蛋白质合成中.
- 肥胖和虚弱相互作用,产生共同和独特的生物学表型,特别是在蛋白质降解途径中.
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