用于抗感染生物应用的压电材料
Chen Chen1,2, Xin Yang1, Yi Liu1,3
1Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha 410008, P. R. China. daixiaohan@csu.edu.cn.
Journal of materials chemistry. B
|October 9, 2024
概括
压电生物材料提供了对抗细菌感染的新策略,增强了组织修复. 本综述探讨了它们的抗菌机制和应用,为未来的再生疗法铺平了道路.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 传染性疾病 传染性疾病
背景情况:
- 细菌感染显著阻碍生物材料在组织修复中的有效性,这是一个关键的临床挑战.
- 目前的抗生素治疗面临局限性,需要针对抗感染生物材料的创新方法.
- 生物材料的表面修饰是实现所需的抗感染特性和生物相容性的关键.
研究的目的:
- 审查用于抗感染和再生应用的压电材料的不同类型和特性.
- 阐明压电材料在促进组织再生方面使用的抗菌机制.
- 讨论压电生物材料在抗击感染方面的当前生物应用和未来前景.
主要方法:
- 关于用于抗感染和再生疗法的压电材料的综合文献综述.
- 对抗菌机制的分析,包括电场编排和压电催化.
- 评估生物应用数据并确定研究缺口.
主要成果:
- 压电材料通过可调的表面的物理化学特性表现出有希望的抗感染特性.
- 关键的抗菌机制包括电场的产生和优化的压电催化.
- 这些机制有效地促进了受感染环境中的组织再生.
结论:
- 压电生物材料在解决与生物材料相关的感染方面取得了重大进展.
- 对挑战和未来方向的进一步研究对于优化其临床翻译至关重要.
- 这一审查为开发下一代抗感染和再生型压电材料提供了基础.
相关概念视频
Bacterial Signaling
31.6K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.6K
Gene Regulation in Microbial Communities: Quorum Sensing
3
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
3


