在完全心脏阻塞的个体中,前垂体激素功能障碍需要起器
Bashir Ahmad Laway1, Arun Viswanath S1, Mohammad Salem Baba1
1Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.
The Indian journal of medical research
|October 9, 2024
概括
患有完全心脏阻塞 (CHB) 患者可能会发展下垂体病,其特征是前垂体激素损失. 这项研究在12个月的随访中发现了CHB个体的显著激素缺乏,突出了潜在的风险.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 神经性缺氧,与创伤性脑损伤和心律失常有关,与缺症有关.
- 患有完全心脏阻塞 (CHB) 的人可能容易患上长期前垂体激素功能障碍.
研究的目的:
- 在CHB后的个体中研究前垂体激素功能.
- 评估CHB患者下垂体病的患病率.
主要方法:
- 一项针对30名接受心脏起器植入的CHB患者的前性队列研究.
- 测量了荷尔蒙水平 (FSH,LH,TSH,TT4,FT4,皮质醇,IGF-1,丸激素,雌激素) 的情况.
- 固定剂量葡萄糖激素刺激试验 (GST) 评估了生长激素 (GH) 和 adrenocorticotrophic 激素 (ACTH) 轴.
主要成果:
- 在12个月的随访中,56.7%的IGF-1水平较低,23%被诊断为生长激素缺乏症 (GHD).
- 20%的患者表现出ACTH缺乏,一个患者有TSH缺乏.
- 总的来说,30%的参与者表现出前垂体激素缺乏.
结论:
- 这项试点研究表明,在12个月的CHB患者中,前垂体激素损失的发生率显著.
- 在CHB患者中未被诊断的下垂体病变可能会导致发病率和死亡率.
- 需要进一步的研究来探索长期后果和管理策略.
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