与视网膜微血管流失相关的因素 视网膜微血管流失因眼内压力升高而引起的初级开角玻璃眼瘤
Alex T Vasconcelos1, Lucas A Rosa2, Lígia I De Fendi2
1Department of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. jspaula@fmrp.usp.br.
概括
急性眼内压力 (IOP) 升高在初级开角青光眼 (POAG) 患者和对照组中显著降低了周周细胞血管密度 (VD). 高IOP和硬是POAG眼睛静脉疾病减少的关键因素.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 周状视网膜的血管密度 (VD) 降低与初级开角玻璃眼 (POAG) 有关.
- 在POAG中影响血管对升高眼内压 (IOP) 的反应的因素仍然在很大程度上未被探索.
研究的目的:
- 为了调查与初级开角青光眼 (POAG) 中周围毛囊血管密度 (VD) 降低相关的风险因素.
- 为了确定急性眼内压力 (IOP) 升高的影响,由眼动力学仪 (OPD) 诱导,在VD.
主要方法:
- 这是一项涉及42只眼睛 (22对照组,20名POAG患者) 的横截面研究.
- 光学连贯断层扫描血管造影 (OCT-A) 用于评估初级目光,引和引与OPD压缩中的周周囊性静脉疾病.
- 多变量回归分析确定了与IOP诱导的VD变化相关的因素.
主要成果:
- 通过OPD压缩引起的急性IOP升高在POAG眼睛和对照组中显著降低了周毛囊静脉疾病.
- 没有观察到任何显著的VD变化,仅仅是由于引述凝视.
- 基线IOP,最大IOP和硬性与POAG眼中的VD减少有显著的相关性.
结论:
- 根据OCT-A的测量,急性IOP升高,而不是引进的目光,可以降低外皮皮膜静脉疾病.
- IOP水平和硬是POAG患者静脉疾病减少的重要因素.
- 高硬度可能会损害眼睛减轻内膜张力波动的能力,可能会影响青光眼的发病和进展.
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