通过三列林刺激试验对中央早熟性青春期的诊断进行LH切断的修订
Paolo Cavarzere1, Marco Sandri2, Marta Arrigoni3,4
1Pediatric Division, Department of Pediatrics, University Hospital of Verona, Verona, Italy.
Endocrine
|October 9, 2024
概括
对于在女孩中早期诊断中部早熟青春期 (CPP) 的建议是,在三极林刺激后,新的素激素 (LH) 值为5IU/L. 这一发现有助于在之前的15 IU/L值之前更早地识别CPP.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 激素检测测试验 激素检测试验
背景情况:
- 女孩的早期青春期 (PP) 定义为8岁之前的larche.
- 中部早发性青春期 (CPP) 的标准诊断涉及性腺激素释放激素 (GnRH) 刺激,对GnRH模拟结果的解释各不相同.
- 之前的15 IU/L的LH后三重林刺激值被发现错过了一些CPP病例.
研究的目的:
- 为了在青春期进展的女孩中为早期的CPP诊断建立一个新的LH值后的三罗林刺激.
- 评估额外的诊断参数,以提高CPP诊断的准确性.
主要方法:
- 186名年龄在1岁至8岁的女孩患有发病,接受了GnRH模拟试验.
- 62名青春期进展迅速的患者重复了三素测试 (100微克/米2).
- 测量了LH,FSH和雌激素水平在三托雷林注射前和注射后4小时.
主要成果:
- 与15 IU/L以下的患者相比,确认轴激活的患者在刺激后的LH水平较高.
- 在轴激活的患者中观察到较高的基底LH,较高的LH/FSH比率和增长速度.
- 统计分析发现一个新的刺激后LH值为5 IU/L.
结论:
- 提议的LH值为5IU/L,在三重林后给药,可以帮助更早地诊断CPP.
- 虽然LH/FSH比率和生长速度与轴激活相关,但与LH水平相结合时,它们并没有显著改善诊断准确性.
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