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德尔菲小组达成共识声明:为欧盟免疫受损人群提供COVID-19疫苗接种建议

Jaya Paranilam¹, Francesco Arcioni², Antonio Franco³

¹ICON Clinical Research, Dublin 18, Ireland.

Infectious diseases and therapy

|October 9, 2024

概括

建议COVID-19疫苗和增强剂用于患有风湿病,脏病,血液病或移植病的免疫受损患者. 专家们就疫苗的安全性和有效性达成共识,强调在这个脆弱人群中需要增强剂.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
临床实践指南临床实践指南

背景情况:

随着COVID-19大流行,全球医疗保健系统面临着巨大压力.
在特定的患者群体 (风湿病,病,血液病,移植) 中缺乏明确的COVID-19管理指南,导致各种做法.

研究的目的:

为免疫功能低下患者制定关于COVID-19疫苗推的临床实践陈述.
评估执业医生对这些共识陈述的同意.

主要方法:

一个涉及16个关键意见领袖 (KOLs) 的德尔菲过程,以创建实践陈述.
一个在线医生调查,以评估与共识陈述的同意.
一个评级系统来确定KOLs之间的共识的强度.

主要成果:

在大多数针对风湿病,病,血液病和移植患者的疫苗推方面达成共识.
专家证实,COVID-19疫苗在这些人群中是安全,有效和耐受的.
强烈到中度的建议支持mRNA疫苗和免疫受损者的增强剂.

结论:

对于各种疾病的免疫力低下患者,COVID-19疫苗和增强剂是必要的.
缺乏共识的领域归因于证据有限或不存在,强调需要进一步研究.

关键词:

在 COVID-19 疫情中,新冠病毒疾病2019年血液学的恶性瘤.免疫力受损的人.患有脏疾病的患者.类风湿性疾病类风湿性疾病这就是SARS-CoV-2病毒.严重急性呼吸系统综合征冠状病毒2 实体器官移植器官移植是什么疫苗疫苗是一种疫苗.

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