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Updated: Jun 11, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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鲁克索利提尼布对JAK2 V617F阳性细胞中免疫检查点分子表达的作用

Jianzhu Fu, Zhiyong Cheng, Lijun Zhang

    Clinical laboratory
    |October 9, 2024
    PubMed
    概括

    鲁克索利提尼布有效地抑制了增殖,并减少了JAK2 V617F阳性髓增殖性瘤中的免疫检查点分子表达. 这种向疗法抑制了癌细胞和调控性T细胞 (Tregs) 中的编程死亡-1 (PD-1) 和编程死亡配体1 (PD-L1).

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