皮质表面积简介介绍了童年不利因素对晚年一般认知能力的影响
Rongxiang Tang1,2, Jeremy A Elman1,3, Chandra A Reynolds4
1Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
概括
童年不利影响以后的生活一般认知能力 (GCA) 通过改变皮质表面积 (SA) 模式. 这种偏离正常大脑组织的偏差与老年成人中减少的GCA有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 发展心理学 发展心理学
背景情况:
- 童年缺点与生命后期的认知和大脑变化有关.
- 具体的神经解剖学途径尚未完全理解.
- 只有大脑总表面积 (SA) 不能解释这些影响.
研究的目的:
- 调查皮层SA的空间形状是否调解了童年不利和晚年一般认知能力 (GCA) 之间的关系.
- 探索从规范性皮质组织的偏差如何与认知功能有关.
主要方法:
- 在477名老年男性 (56-72岁) 中评估了童年不利情况和GCA.
- 使用结构性MRI测量皮质SA,并计算皮质SA概况.
- 员工调解分析以测试通过皮质SA档案对GCA不利的间接影响.
主要成果:
- 皮层SA特征约占童年不利状况对晚年GCA的影响的1.31%.
- 较高的童年劣势与皮质SA模式与主要梯度的较大偏差相关.
- 这种偏差与较低的GCA相关.
结论:
- 儿童时期的缺点可能会通过破坏皮质表面积的空间组织来影响以后的生活GCA.
- 偏离规范性皮质组织代表了一个潜在的神经生物学机制,将早期的生活逆境与认知衰老联系起来.
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