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Updated: Jun 11, 2025

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在食道发育和恶性瘤中,p63的表观遗传调节阻断了状到神经内分泌的转差

Yongchun Zhang1,2,3, Dimitris Karagiannis4, Helu Liu2,3,5

  • 1State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.

Science advances
|October 9, 2024
PubMed
概括

转录因子p63调节食道中的细胞命运,在状和神经内分泌类型之间切换. 它的沉默由EZH2促进癌症,而它的恢复驱动食道神经内分泌癌中的状分化.

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