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Updated: Jun 11, 2025

Demonstration of Heterologous Complexes formed by Golgi-Resident Type III Membrane Proteins using Split Luciferase Complementation Assay
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SLC26A4-AP-2 mu2相互作用调节了内淋巴囊中SLC26A4等离子体膜的丰富性

Hyun Jae Lee1, Cristina Fenollar-Ferrer1,2, Kevin Isgrig3

  • 1Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

Science advances
|October 9, 2024
PubMed
概括

适应蛋白2 (AP-2) 复合体的micro2子单元调节了SLC26A4 (Pendrin) 在血中的丰富性. 这种相互作用对于正常的内耳液体再吸收和预防听力损失至关重要.

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Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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