多种药物耐药性通过马莱胺相互作用逆转. 一个新兴领域的生物和合成概述

Edson D Hernández-Velázquez1, Angelica J Granados-López2, Jesús Adrián López2

  • 1Campus Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, 36050, Guanajuato, Gto., México.

概括

多种药物耐药性 (MDR) 是一个主要的健康威胁. 本综述探讨了maleimide合成作为一种潜在的策略,通过向P-gp,MRP1和BCRP等关键蛋白来逆转MDR.

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