相关实验视频

Updated: Jun 11, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

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循环中的JKAP水平可能与产后焦虑和抑郁相关,因为它与T辅助细胞17相互作用

Jing Zhang1, Cui Li2, Zhuo Chen1

  • 1Department of Obstetrics, Xingtai People's Hospital, Xingtai, China.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
|October 9, 2024
PubMed
概括

在患有焦虑或抑郁症的产后妇女中,Jun N-终端酶通路相关酸酶 (JKAP) 水平较低. 减少JKAP和增加的T辅助17 (Th17) /调节性T (Treg) 细胞与分娩后的心理健康有关.

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C07:13

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相关概念视频

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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