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在先天性细胞大脑病毒中单边感应神经听力损失的回顾性观察性研究
Layah Alkoby-Meshulam1, Daisy Rosenthal-Shtern1, Ori Snapiri1
1From the Department of Pediatrics C.
The Pediatric infectious disease journal
|October 9, 2024
概括
先天性细胞巨乳病毒 (cCMV) 可以导致婴儿单方面听力损失. 抗病毒治疗显示出不同的结果,有些人听力损失随着时间的推移而改善,而另一些人则恶化.
科学领域:
- 儿科 儿科 儿科
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 先天性细胞大脑病毒 (cCMV) 是儿童感觉神经听力损失的主要非遗传原因.
- 感觉神经听力损失可以表现为单边 (UHL) 或双边 (BHL),并可能随着时间的推移而进展.
研究的目的:
- 描述cCMV相关单边听力损失的婴儿的临床表现和长期随访.
- 分析受影响和不受影响的耳朵在婴儿治疗cCMV诱导的UHL的结果.
主要方法:
- 在以色列施耐德医疗中心进行了一项为期16年的回顾性研究.
- 纳入标准:出生时患有UCL的cCMV婴儿,在4周内接受抗病毒治疗,并进行≥1年的随访.
- 收集了关于听力损失严重程度,随时间变化和治疗反应的数据.
主要成果:
- 分析了67名出生时患有UHL的婴儿,17名轻度,22名中度,28名严重.
- 在轻度治疗组中,41%的情况有所改善,47%的情况没有变化,12%的情况恶化.
- 在中度病例组中,41%的病例有所改善,32%的病例没有变化,27%的病例恶化;4%的严重病例有所改善. 6%的最初正常的耳朵恶化.
结论:
- 与cCMV相关的UHL表现出不同的临床轨迹,包括自发改善和恶化.
- 了解这些模式对于指导受影响儿童的医疗和手术干预决策至关重要.
- 长期跟踪对于管理cCMV相关的听力损失至关重要.
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