儿科血性恶性病的侵入性候群病:增加了与Candida tropicalis传播的风险
Amira M Said1, Faraz Afridi2, Michele S Redell3
1From the Department of Pediatrics, Section of Pediatric Infectious Diseases, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.
The Pediatric infectious disease journal
|October 9, 2024
概括
非白虫Candida (NAC),特别是Candida tropicalis,是患有血液恶性瘤的儿童侵入性白病的主要原因. 早期对眼内角膜炎的查对于这些高风险患者的更好的结果至关重要.
科学领域:
- 儿科血液学 瘤学 儿科血液学
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
背景情况:
- 侵袭性真菌病 (IFD) 是患有血液恶性瘤的儿科患者的一个重大问题.
- 非白的Candida (NAC) 种类越来越多地与侵入性白病 (IC) 有关,通常与更差的预后有关.
- 了解特定物种的流行病学和结果对于有效管理至关重要.
研究的目的:
- 为了比较流行病学,风险因素,器官扩散,生物标志物和患有血液恶性瘤的儿童侵袭性候群病 (IC) 的结果.
- 评估抗真菌耐药性的趋势随着时间的推移.
- 为了确定IC呈现和预后的特定物种差异.
主要方法:
- 在两个中心 (2011-2022) 的53名儿科患者 (0-18岁) 血液恶性瘤和IC的回顾性图表审查.
- 收集的数据包括人口统计,宿主因素,Candida物种,抗真菌敏感性,治疗和结果.
- 在物种层面进行分析以确定差异.
主要成果:
- 红细胞结核病的发病率为每1000名白血病和淋巴瘤患者中29例.
- 最常见的物种是Candida tropicalis (30%),其次是Candida albicans (25%).
- 热带菌感染与传播到眼睛,脏和皮肤的更高速率有关. 在24%的患有扩张视网膜检查的患者中观察到眼内角膜炎,这通常与长期的候选血症有关. 12周的原始死亡率为16.9%.
结论:
- 非白虫Candida (NAC),特别是C. tropicalis,在儿科血性恶性瘤患者中主导了IC病例.
- 查眼内角膜炎对于管理该群体的眼内角膜炎至关重要.
- 需要进一步的研究来完善眼内角膜症的查标准.
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