多发性硬化症患者中的癌症风险:为期10年的全国性回顾性队列研究
Chloe Pierret1, Aurelien Mulliez1, Christine Le Bihan-Benjamin1
1From the EHESP, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309 (C.P., E.L.), Rennes University; Clermont-Ferrand University Hospital Center (A.M., X.M.); Survey, Data Science and Assessment Division (C.L.B.-B., P.-J.B.), French National Cancer Institute-InCA, Boulogne-Billancourt; and NeuroDol U1107 (X.M.), Clermont Auvergne University, Clermont-Ferrand, France.
Neurology
|October 9, 2024
概括
多发性硬化症 (PwMS) 患者的整体癌症风险略有增加,因癌症类型和年龄而异. 这可能受到监视偏见和不同选实践的影响.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 关于多发性硬化症 (PwMS) 患者癌症风险的文献存在分歧.
- 这项研究解决了需要明确比较PwMS与普通人群之间的癌症风险的需求.
研究的目的:
- 为了比较PwMS中的癌症发病率与法国的相匹配的一般人口样本.
- 在PwMS中调查癌症类型,年龄和性别的癌症风险变化.
主要方法:
- 一项为期10年的全国性追溯匹配队列研究 (2012-2021年) 使用法国行政医疗保健数据.
- 通过长期疾病状况,住院和MS特定药物补偿来确定PwMS;对照组与4:1匹配.
- 使用Fine和Grey模型分析的癌症发病率和危险比率 (HRs);癌症查参与率相比较.
主要成果:
- 总体癌症发病率略高于PwMS (799/100,000 PYs) 与对照组 (736/100,000 PYs) 相比,HR为1.06.
- 观察到膀,大脑和宫癌的风险增加;前列腺,乳腺和结直肠癌的风险降低.
- 年轻的PwMS (<55岁) 的风险较高,老年PwMS (≥65岁) 的风险较低;PwMS中发现的查参与率较低.
结论:
- 在PwMS中,癌症风险略高,特别是在某些癌症类型中,可能受到监测偏差的影响.
- 与年龄相关的风险波动表明,代际查实践与风险因素之间的相互作用.
- 对监测偏差和年龄特异性风险因素的进一步研究是有必要的.
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