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在回顾性儿科队列中的多发性硬化症前

Kelsey Barter¹, Siefaddeen Sharayah¹, Urmi Mange¹

¹Department of Neurology, Washington University in St. Louis, St. Louis, Missouri.

Pediatric neurology

|October 9, 2024

概括

儿科多发性硬化症 (MS) 患者在他们的第一个脱髓化事件 (FDE) 发生前两年显示出更多的医疗保健使用和各种症状,包括头痛. 这突显了儿科发病性MS (POMS) 中潜在的前性阶段.

科学领域:

儿科神经学儿科神经学
脱线性疾病脱线性疾病
多发性硬化症的病理生理学

背景情况:

在多发性硬化症 (MS) 中,在第一个脱髓化事件 (FDE) 发生之前,医疗保健利用率增加表明了前进阶段.
与成年人相比,对于儿科发病的MS (POMS) 中的这个前期阶段存在有限的研究.
了解POMS早期症状和医疗模式对于及时诊断和干预至关重要.

研究的目的:

分析儿童发病性多发性硬化症 (POMS) 患者在FDE前两年的医疗保健利用模式.
为了识别和描述POMS患者在FDE之前经历的前兆症状.
将FDE前一年的医疗保健遭遇与前一年进行比较.

主要方法:

对21例POMS病例的回顾性分析,在FDE之前至少有两年的医疗记录.
从小儿多发性硬化症和脱线疾病中心 (2011-2021) 的患者收集的数据.
评估门诊,住院和办公室访问,包括症状记录.

主要成果:

在FDE前一年 (96个相互作用) 与前一年 (77个相互作用) 相比,观察到医疗保健利用率增加.
发现神经病学相关接触 (P < 0.001) 和整体办公室呼叫 (P = 0.01) 的显著增加.
常见的神经疾病包括头痛 (28.6%),视觉 (19.0%),感官 (14.3%) 和平衡问题 (14.3%). 在28.6%的患者中,精神病投诉存在.
非神经学的投诉包括感染,皮肤和肌肉骨问题以及伤害.

结论:

在POMS队列中,FDE之前的医疗保健使用量增加,与成年人群的发现保持一致.
突发性POMS的特点是多样化的症状,头痛是最常见的神经学投诉.
这些发现强调了识别儿科多发性硬化症潜在的前性阶段中微妙和多样化的症状的重要性.

关键词:

第一个脱髓化事件.多发性硬化症是多发性硬化症.神经免疫学神经免疫学儿科发病的多发性硬化症产节性多发性硬化症是多发性硬化症.

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