在自身造血干细胞移植中单单体输血政策:少不坏不坏
Javier Marco-Ayala1, Pedro Asensi Cantó2, Marina Suarez2
1Hematology Department, University Hospital Morales Meseguer, Murcia, Spain; Department of Medicine, University of Murcia, Murcia, Spain.
Transfusion medicine reviews
|October 9, 2024
概括
实施单个单位红细胞 (1-RBC) 输血政策可以显著减少在接受自身干细胞移植 (ASCT) 患者的血液使用,而不会影响临床结果.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
背景情况:
- 单个单位红细胞 (1-RBC) 输血政策减少了血液病患者的输血负担.
- 自主干细胞移植 (ASCT) 后1-RBC政策的影响仍未得到充分研究.
研究的目的:
- 评估1RBC政策对接受ASCT的患者输血负担和临床结果的影响.
主要方法:
- 187名患者在1-RBC政策下 (2019年5月至2022年12月) 与153名患者在双单元政策下 (2019年1月至2019年4月) 的回顾性比较.
- 对输血需求,利用和临床结果的分析.
主要成果:
- 1-RBC政策减少了32%的红细胞利用率和30日的红细胞输血 (中位数为2对3单位;P<.0001).
- 在输血发作,停留时间,排出血红蛋白或30天死亡率方面没有观察到显著差异.
结论:
- 过渡到1-RBC政策是减少ASCT患者红细胞输血的有效策略.
- 这一政策显著减少了血液的利用,而不会对关键的临床结果产生不良影响.
相关概念视频
Bone Marrow Sampling and Transplants
312
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
312
Blood Transfusion and Agglutination
10.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.7K
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Multipotency of Hematopoietic Stem Cells
3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Blood Transfusion
525
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
525


