在后急性Covid-19患者中,低场MRI肺部不透明度严重程度与DLCO降低有关
Lea Azour1, Leopoldo N Segal2, Rany Condos2
1Department of Radiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, United States of America; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America.
后急性COVID-19患者的低场MRI肺部不透明度严重程度与一氧化碳 (DLCO) 的扩散能力降低相关. 这种成像发现与患者报告的结果无关.
科学领域:
- 医学成像医学成像
- 肺部病理学 肺部病理学
- 传染病 传染病 传染病 传染病
背景情况:
- 后急性COVID-19可能导致持续的呼吸系统问题.
- 低场MRI为肺部成像提供了一种潜在的可访问方法.
- 评估肺不透明度的严重程度对于了解COVID-19的长期影响至关重要.
研究的目的:
- 评估后急性COVID-19患者的低场MRI肺不透明度严重性的临床意义.
- 为了确定肺不透明度严重程度和肺功能之间的相关性.
- 评估肺不透明度严重程度与患者报告的结果之间的关联.
主要方法:
- 在62名后急性COVID-19患者的低场MRI扫描后期分析.
- 核磁共振 (MRI) 肺不透明度严重程度与肺功能测试 (PFTs),6分钟步行测试 (6mWT) 和症状清单 (SI) 的相关性.
- 统计分析包括带Bonferroni校正的单变量,相关性和多变量模型.
主要成果:
- 在低场MRI上,肺不透明度的严重程度与一氧化碳 (%DLCO) 扩散能力的降低有显著关联.
- 较高的肺不透明度严重度四分位数与降低的%DLCO,预测的肺总容量 (TLC) 和强迫生命能力 (FVC) 相相关.
- 肺不透明度严重程度和患者报告的结果 (PRO) 之间没有发现显著的关联.
结论:
- 低场MRI肺部不透明度严重程度是COVID-19后急性COVID-19中受损气体交换的相关成像生物标志物.
- 尽管与客观肺功能测量有相关性,但MRI不透明度严重程度与患者报告的结果没有相关性.
- 进一步的研究可能会探索低场MRI在治疗长期COVID呼吸系统瘤方面的临床实用性.
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