在辅助生殖技术后出生的儿童中,兰格汉斯细胞囊细胞形成
Carrie L Williams1, Kathryn J Bunch2, Charles Stiller3
1UCL Great Ormond Street Institute of Child Health, London, UK.
Reproductive biomedicine online
|October 9, 2024
概括
通过细胞内精子注射 (ICSI) 出生的儿童和患有男性因子不孕症的儿童具有更高的兰格汉斯细胞囊细胞症 (LCH) 风险. 总体来说,辅助生殖技术 (ART) 的风险并没有显著增加,但需要进一步研究.
科学领域:
- 生殖医学 生殖医学
- 儿科瘤学 儿科瘤学
- 流行病学 流行病学
背景情况:
- 辅助生殖技术 (ART) 涵盖了各种帮助怀孕的程序.
- 朗格汉斯细胞囊细胞症 (LCH) 是一种罕见的疾病,主要影响儿童.
研究的目的:
- 调查通过辅助生殖技术 (ART) 怀孕的儿童患朗格汉斯细胞囊细胞瘤 (LCH) 的风险.
主要方法:
- 在英国建立了一个大量的ART后出生的儿童队列.
- 该队列与国家癌症登记处联系在一起,以确定LCH病例.
- 标准化发病率 (SIR) 通过将观察到的与预期的LCH病例进行比较来计算.
主要成果:
- 在118,155名ART受孕儿童中观察到8例LCH病例,而预期为3.75例 (SIR 2.135,无意义).
- 在注射细胞内精子 (ICSI) (SIR 4.02) 和男性因子不孕症 (SIR 5.41) 后出生的儿童中,LCH发病率明显较高.
- 大多数LCH病例呈现为单一系统疾病.
结论:
- 在ICSI后出生的孩子和那些父母经历过男性因子不孕症的孩子,患LCH的风险增加.
- 虽然整体ART队列显示不显著的LCH风险过剩,但绝对风险仍然很小.
- 需要进一步的研究,以充分了解与ART相关的LCH风险,考虑到这种情况的罕见性.
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