激活的交感神经中风后降低了Toll-like受体5的调节,并破坏了肠道粘膜屏障
Huidi Wang1, Jie Li1, Guangyan Wu1
1Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China.
Cell reports. Medicine
|October 9, 2024
概括
脑卒中通过激活交感神经系统来破坏肠道粘膜屏障,从而降低了Toll-like受体5 (TLR5) 的调节. 这允许有害细菌入侵,使中风的结果恶化.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 缺血性中风增加了肠道的透性,与粘膜屏障的破坏有关.
- 在中风后的肠道屏障功能障碍背后的精确机制尚未完全理解.
研究的目的:
- 为了阐明在缺血性中风后肠道粘膜屏障破坏的机制.
- 确定肠道微生物群和神经通路在中风引起的肠道损伤中的作用.
主要方法:
- 在小鼠中研究了中风后的粘液破坏时间和杯状细胞功能.
- 使用了没有细菌的小鼠模型,并移植了特定的细菌 (Helicobacter).
- 评估了托尔类受体5 (TLR5) 表达,鞭毛素特异性IGA和抗菌.
- 检查了交感神经激活和诺拉地林水平的影响.
主要成果:
- 粘液破坏在中风后2小时开始,独立于杯状细胞的功能.
- 鞭状细菌,比如Helicobacter,繁殖并入侵粘液层.
- 减少TLR5信号传递,鞭毛素特异性IGA和抗菌促进了细菌入侵.
- 交感神经激活降低了肠道TLR5的调节,加剧了粘液损伤.
- 血清诺亚上升与鞭毛素水平相关,患者预后较差.
结论:
- 肠道微生物群,特别是鞭状细菌,在中风引起的粘膜屏障破坏中发挥着关键作用.
- 交感神经的激活降低了TLR5的调节,损害了肠道屏障的完整性.
- 这种神经通路为减轻与中风相关的肠道损伤提供了一个新的治疗点.
相关概念视频
01:17Sympathetic Activation
5.1K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.1K
01:25The Sympathetic Nervous System
94.6K
Overview
94.6K
01:30Parasympathetic Signaling
1.8K
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
The effects of...
1.8K
01:05Physiology of Enteric Nervous System and Gut Health
229
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
229
01:17Irritable Bowel Syndrome I: Introduction
254
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
254