全球运动动力学 - - 在分布在整个大脑的记录中,对运动行为的不变神经表示
Maarten C Ottenhoff1, Maxime Verwoert1, Sophocles Goulis1
1Department of Neurosurgery, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, The Netherlands.
Journal of neural engineering
|October 9, 2024
概括
全球大脑活动模式预测跨任务和个体的运动. 这项研究揭示了广泛的神经动力学,增强了我们对运动控制和大脑功能的理解.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 众所周知,与运动相关的神经活动是普遍存在的,在动物和一些人类大脑区域中观察到大脑范围的相关性.
- 然而,人类大脑中与运动相关的神经活动的全球模式的程度在很大程度上仍未被探索.
研究的目的:
- 通过解码方法捕捉和表征大脑范围内的运动神经相关物.
- 在任务和参与者之间调查全球运动相关神经动态的存在和稳定性.
主要方法:
- 在八名患者中使用立体电脑学 (SEEG) 记录了侵入性电生理学数据,他们执行了执行和想象的抓取任务.
- 利用低维表示和里曼解码器来从休息试验中分类运动.
- 进行了除分析和转移学习,以评估所识别的动态的稳定性和概括性.
主要成果:
- 揭示了全球神经动态,可以预测不同任务和参与者的运动.
- 证明了这些动态的显著稳定性,即使有信息丢失 (消去分析).
- 通过转移学习可以预测参与者的运动,这表明跨参与者的概括性.
结论:
- 可解码的,全球运动相关的神经动态存在于低维空间,几乎是大脑范围,并且存在于所有参与者中.
- 这些发现支持对运动控制进行大脑范围调查的更广泛范围.
- 这些结果可能有助于组合来自多个参与者的数据集,并开发无校准的神经解码器.
更多相关视频
11:20Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning
Published on: June 2, 2014
12.0K
11:31Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks
Published on: December 5, 2014
15.1K
相关概念视频
01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
01:18Functions of the Nervous System
The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...
01:23Propagation of Action Potentials
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
01:13Functional Brain Systems: Reticular Formation
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
01:28Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
01:28Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...