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Updated: Aug 14, 2026

Generation of Stable Human Cell Lines with Tetracycline-inducible Tet-on shRNA or cDNA Expression
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产生和应用CES1-淘汰赛Tet-Off调节的CYP3A4和UGT1A1-表达的Caco-2细胞

Michika Murata1, Kentaro Okada2, Masaki Takahashi3

  • 1Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

Toxicology letters
|October 9, 2024
PubMed
概括

研究人员为药物开发开发开发了改进的Caco-2细胞. 这些细胞精确地模拟了小肠中的药物吸收和新陈代谢,解决了以前模型的局限性,以加强制药研究.

关键词:
这就是为什么我会说CESCESCES.在 CYP3A4 中.在Caco-2细胞中.药物代谢药物代谢美国UGT1A1

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