早期生活中的空气污染暴露和儿童的甲状腺功能:前性队列研究
You Joung Heo1, Yun Jeong Lee2, Soon Tae Kim3
1Department of Pediatrics, Gwangmyeong Hospital, Chung-Ang University School of Medicine, Gwangmyeong, Republic of Korea.
Environmental pollution (Barking, Essex : 1987)
|October 9, 2024
概括
早期接触细颗粒物 (PM2.5) 影响儿童甲状腺功能. 虽然孕期PM2.5对甲状腺激素有逆效应,但儿童PM2.5暴露与甲状腺激素水平有积极关联.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 关于早期生活环境空气污染和儿童甲状腺功能的研究有限.
- 细颗粒物 (PM2.5) 和二氧化 (NO2) 是常见的空气污染物,具有潜在的健康影响.
- 甲状腺激素对儿童发育至关重要.
研究的目的:
- 研究儿童早期暴露于PM2.5和NO2与甲状腺功能之间的关系.
- 分析暴露时间 (孕期与童年) 如何影响这些关联.
主要方法:
- 在韩国农村小组中对684名儿童进行了长度研究 (2012-2020年).
- 在2,4,6和8岁时测量甲状腺激素 (TSH),triiodothyronine和自由甲状腺素水平.
- 在怀孕期间和评估前一年的住宅平均PM2.5和NO2暴露的估计.
主要成果:
- 第一个三个月的PM2.5增加与4岁和6岁的TSH水平相反相关.
- 儿童PM2.5暴露与4岁和6岁的TSH水平有关.
- 儿童PM2.5暴露与8岁时的自由甲状腺素水平相反相关;没有发现NO2相关性.
结论:
- 暴露于PM2.5的时间影响了儿童的甲状腺激素水平,孕期暴露显示了反向关系和儿童暴露的积极关系.
- 这些发现凸显了空气污染对甲状腺发育的复杂影响.
- 需要进一步的研究来探索空气污染对甲状腺功能的长期影响和潜在机制.
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