在环境UVB暴露下,甲对皮肤敏感化的过敏潜力和分子机制
Sunil Kumar Patel1, Apeksha Vikram1, Diksha Pathania1
1Photobiology Laboratory, Drug and Chemical Toxicology Group, FEST Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan 31, Mahatma Gandhi Marg, Lucknow, 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India.
Chemosphere
|October 9, 2024
概括
香水成分肉甲 (CA) 可以在阳光下恶化皮肤过敏. 这项研究揭示了cis-CA增强了过敏潜力,通过UVB暴露和氧化应激激活了免疫路径.
科学领域:
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 化品中的香水,如肉甲 (CA),是常见的皮肤敏感剂.
- 目前尚不清楚CA的UVB吸收能力以及CA在UVB下增强皮肤敏感性的潜力.
研究的目的:
- 在环境UVB辐射下研究CA的过敏潜力.
- 阐明CA诱导的皮肤敏感化的分子机制.
主要方法:
- 使用了in-silico,in-chemico和in-vitro的方法.
- 分析了CA异构,DPRA测定,分子对接,ROS水平和基因表达 (Nrf2,Catalase,MMP-2/9).
- 通过CD86,细胞和TLR4通路评估了THP-1细胞的激活.
主要成果:
- 紫外线暴露诱导了转向cis-CA的异体化,cis-CA显示出增强的过敏潜力.
- 在KeratinoSens细胞中,CA和UVB上调了ROS,Nrf2,Catalase和MMP-2/9.
- 通过ROS,细胞和TLR4通路,CA激活了THP-1细胞.
结论:
- 肉甲的过敏潜力被UVB暴露放大,特别是cis-同位素.
- 机制包括氧化应激,免疫细胞激活和特定基因通路调节.
- 这些发现有助于管理由香水引起的过敏皮肤反应,而这些过敏皮肤反应则会因阳光而恶化.
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