[患有骨矿物质密度低的患者的甲状腺功能过强症,用佐莱德龙酸或登苏马布治疗]
Carmen Riesco-Bárcena1, José Ivorra-Cortés1, Elena Grau-García1
1Servicio de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, España.
Medicina clinica
|October 9, 2024
概括
这项研究发现,在接受佐列龙酸 (ZA) 和登苏马布治疗的患者中,特别是后者,甲状腺功能障碍的发病率很高. 偏甲状腺激素 (PTH) 水平升高并没有影响短期内骨矿物质密度 (BMD) 的演变.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 偏甲状腺功能障碍是骨质疏松症治疗中的一个问题.
- 佐乐德罗尼酸 (ZA) 和德诺苏马布是常见的抗吸收剂.
- 了解药物对甲状腺前激素 (PTH) 的特定影响至关重要.
研究的目的:
- 为了确定ZA或denosumab的患者甲状腺功能障碍症的患病率.
- 探索甲状腺功能障碍症和其他临床参数之间的关系.
- 评估甲状腺功能障碍症对骨矿物质密度 (BMD) 变化的影响.
主要方法:
- 追溯观察性研究.
- 包括患有骨质疏松症/骨质疏松症的患者,接受ZA或denosumab治疗≥2年.
- 排除了基线甲状腺功能增强症或低膜过率的患者.
主要成果:
- 与ZA使用者相比,在denosumab使用者中观察到较高的PTH升高的发病率.
- 持久性甲状腺功能障碍症在代诺苏马布组 (19.51%) 与ZA组 (6.13%) 中明显更常见.
- 升高的PTH与膜过率和蛋白校正的反相关性.
结论:
- 在接受ZA和denosumab治疗的患者中,经常观察到过多甲状腺功能障碍症.
- 德诺苏马布治疗与偏甲状腺功能障碍症的发病率较高有关.
- 增加的PTH水平似乎不会影响这些患者的短期BMD演变.
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