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药剂师干预慢性脏疾病的影响:元分析
Ashkon Ardavani1, Ffion Curtis2, Ellen Hopwood1
1NIHR Applied Research Collaboration East Midlands (ARC-EM), Leicester Diabetes Centre, University of Leicester, Leicester, UK.
概括
药剂师干预在慢性病 (CKD) 管理方面显示出混合的结果,改善了一些临床和人文结果,但没有其他结果. 需要进一步的研究来优化药剂师在CKD护理中的角色.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 卫生经济学 卫生经济学
背景情况:
- 药剂师拥有独特的治疗知识来管理慢性病 (CKD).
- 关于药剂师对CKD进行干预的经济,临床和人文成果 (ECHO) 的数据有限.
- 这次审查在PROSPERO (CRD42022304902) 进行了前性注册.
研究的目的:
- 系统地审查和元分析药剂师干预措施对成年CKD患者ECHO结果的影响.
- 综合来自随机对照试验 (RCT) 的证据,评估药剂师在CKD管理中的投入.
主要方法:
- 对32项涉及患有CKD的成年人RCT的系统审查和元分析.
- 数据提取的重点是经济,临床和人文成果.
- 随机效应模型元分析和效应图的方向用于数据合成.
主要成果:
- 药剂师的干预显著改善了系统血压和血红蛋白水平.
- 在透析血压,eGFR,肌素或LDL胆固醇方面没有观察到显著改善.
- 在临床和经济结果方面报告了混合的发现,在患者满意度和知识等人文结果方面注意到了改善.
结论:
- 药剂师的干预在CKD患者的各种ECHO结果中产生了混合的结果.
- 未来的研究应该专注于强大的研究设计,纳入药剂师在处方和解除处方方面的角色.
- 这些发现旨在为未来的研究和临床实践提供药剂师领导的CKD管理的信息.
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