在早产婴儿的鼻内母乳治疗后的结果,这些婴儿有腹腔内出血
Alessia Gallipoli1, Sharon Unger2, Amr El Shahed1,3
1Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.
概括
鼻内母乳 (IHM) 显示出治疗早产婴儿内腔室出血 (IVH) 的脑损伤的潜力. 根据这项试点研究的有希望的结果,建议进行进一步的动力试验.
科学领域:
- 新生儿神经学 新生儿神经学
- 再生医学是一种再生医学.
- 儿科重症监护中心儿童重症监护中心
背景情况:
- 腹腔内出血 (IVH) 是早产婴儿脑损伤的重要原因之一.
- 新鲜人乳 (HM) 含有潜在的治疗应用的干细胞 (SCs).
- 鼻内注射HM (IHM) 为SCs向大脑提供了一种新的输送途径.
研究的目的:
- 描述一项试点研究的结果,该研究调查了IVH的早产婴儿的鼻内母乳 (IHM).
- 为了评估短期的神经学结果和纵向后续测试.
- 为了比较IHM治疗婴儿的结果与历史人类母乳养的对照.
主要方法:
- 一项试点研究涉及早产婴儿 (<33周怀孕) 与IVH接受IHM至28天的年龄.
- 短期和后续结果与哺乳母乳的人类历史对照结果的比较.
- 使用线性混合模型进行统计分析,用于纵向数据和加权G计算治疗效应.
- 用于调整IVH等级,妊娠年龄和性别的倾向得分模型.
主要成果:
- 37名婴儿接受了IHM,与191名历史对照组相比;35.1%的IHM患者有3-4级IVH,而对照组的17.8%.
- 在IHM患者中,25.7%的患者出现了后出血性心室扩张.
- 权衡结果有利于4-12个月和18个月的IHM纠正年龄,尽管在统计学上不显著.
结论:
- 这一第一阶段的试点研究表明,鼻内母乳 (IHM) 是对早产婴儿脑损伤的可行的干预措施.
- 需要进一步的强化临床试验来证实IHM的疗效.
- 这项研究以clinicaltrials.gov标识符NCT04225286.gov注册.
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