对于结肠直肠瘤的非侵入性查测试,可调整的阳性值可以提高查计划的有效性和可行性
Graeme P Young1, Carlo Senore2, Ronald Schoengold3
1Flinders Cancer Research, Flinders University, Bedford Park, Adelaide, SA, 5042, Australia. graeme.young@flinders.edu.au.
Digestive diseases and sciences
|October 9, 2024
概括
在结直肠癌查中调整便血红蛋白 (f-Hb) 值可以提高测试准确性和结直肠镜工作负载平衡. 灵活的门对于新的非侵入性测试至关重要,以满足各种医疗保健需求.
科学领域:
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
- 公共卫生 公共卫生
背景情况:
- 两步结肠直肠癌 (CRC) 查使用非侵入性测试,如便免疫化学测试 (FIT),以确定需要结肠镜的人.
- 便中的血红蛋白度 (f-Hb) 是FIT的关键预测指标,指导对随访程序的患者的选择.
研究的目的:
- 评估可调节的f-Hb阳性值在CRC查中的意义.
- 评估f-Hb对结直肠瘤的预测价值及其对新的非侵入性试验设计的影响.
主要方法:
- 进行了关于定量FIT和阳性值选择的文献综述.
- 利用来自大量人群的f-Hb数据来建模调整阳性值对查计划结果的影响.
主要成果:
- f-Hb阳性值有效预测结直肠瘤,值水平和计划结果之间存在复杂的关系.
- 调整值会影响临床准确性 (灵敏度/特异性) 和结肠镜工作量.
- 门设置影响人口CRC死亡率/发病率,计划可行性和成本效益.
结论:
- 开发新的非侵入性CRC查测试,通常使用机器学习算法,由于固定的准确性和工作负载影响,提出了挑战.
- 在为新测试设置阳性度值时,灵活性至关重要,以使其与所需的查计划结果和医疗保健系统限制保持一致.
- 为了有效地部署非侵入性查策略,必须考虑测试批准,资金和实施的司法区别.
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