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Updated: Jun 11, 2025

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CYPHER:具有高强度和持久效果的催化细胞外向蛋白质降解

Zachary R Crook1,2,3, Gregory P Sevilla1,2,3, Pamela Young2

  • 1Cyclera Therapeutics Inc, Seattle, WA, 98115, USA.

Nature communications
|October 9, 2024
PubMed
概括

CYpHER技术提供了一种新的方法,通过利用pH依赖的内溶体递送和回收利用向蛋白质降解. 这种方法提高功效,减少治疗由多种蛋白质功能驱动的疾病的非目标风险.

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