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Updated: Aug 11, 2026

Derivation of Glial Restricted Precursors from E13 mice
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Published on: June 20, 2012

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用CRISPR编辑的人类ES衍生的寡类细胞前代细胞改善动物的复髓化

Laura J Wagstaff1, Nadine Bestard-Cuche2, Maja Kaczmarek2

  • 1Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK. laura.wagstaff@ed.ac.uk.

Nature communications
|October 9, 2024
PubMed
概括

这项研究基因编辑了人类的寡头细胞原生细胞 (OPCs),以克服多发性硬化症 (MS) 病变抑制剂. 移植后编辑的OPC在动物模型中增强了回髓化,为进展性MS提供了潜在的治疗方法.

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...