在ABCD样本中,研究大脑结构和外部化精神病理的不同维度之间的横截面和纵向关系
Hajer Nakua1,2, Lee Propp1,3, Anne-Claude V Bedard3
1Margaret and Wallace McCain Centre for Child Youth and Family Mental Health, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
概括
儿童的外部化行为与大脑结构有关. 特定的额叶厚度预测了随着时间的推移症状的减少,为神经生物学发展和精神病理学提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 在童年时期将精神病理外部化预测了终身的负面结果.
- 患有外化症状的儿童往往表现出情绪失调和冷酷无情 (CU) 的特征.
- 了解这些特征的神经生物学基础对于早期干预至关重要.
研究的目的:
- 检查儿童外化精神病理学,情绪失调和CU特征的横截面和纵向神经相关性.
- 识别与这些行为维度相关的特定大脑结构.
- 调查早期大脑结构是否能预测两年内行为变化.
主要方法:
- 利用了青少年大脑认知发展研究 (N=10,534) 的基线,1年和2年数据.
- 采用线性混合效应模型来分析大脑结构 (皮层厚度,皮层下体积) 和行为指标之间的关联.
- 专注于前皮和条形状区域.
主要成果:
- 在横截面上,右面正面中额和双边环状轨道的皮层厚度与CU特征正相关.
- 在纵向上,在左侧三角体和面状中额回形中,较大的基线皮质厚度预测了两年内外化症状的减少.
- 研究结果表明,不同的前和状区域与外部化精神病理学的不同方面有关.
结论:
- 特定的前临界大脑区域与童年外部化精神病理学的不同维度有独特的关联.
- 儿童早期的大脑结构为行为和精神病理学的发展轨迹提供了宝贵的见解.
- 这些发现突出了儿童疾病早期干预的潜在神经生物学目标.
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