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Updated: Jun 11, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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通过DDI2激活NFE2L1-ubiquitin-proteasome系统,可以防止ferroptosis发生

Anahita Ofoghi1, Stefan Kotschi1, Imke L Lemmer1,2

  • 1Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.

Cell death and differentiation
|October 9, 2024
PubMed
概括

作为细胞死亡途径的铁亡,涉及到核因子红色素-2衍生,类似-1 (NFE2L1) 和全方位蛋白酶体系统 (UPS). 我们发现DNA损伤诱导性1同源2 (DDI2) 对NFE2L1激活至关重要,影响铁和蛋白质酶功能.

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