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Updated: Aug 10, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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对母体IL-17A的胚胎受限反应在小鼠后代中促进神经发育障碍

David Andruszewski1,2,3, David C Uhlfelder1,2, Genni Desiato4,5

  • 1Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Molecular psychiatry
|October 9, 2024
PubMed
概括

产前暴露于17A型白内素 (IL-17A) 可能导致行为问题. 一个新的PRIMA-17小鼠模型显示,IL-17A印记导致后代的沟通缺陷和焦虑.

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...