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Updated: Jun 11, 2025

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在行为时间尺度可塑性中的状,延迟的,随机的CaMKII激活

Anant Jain1,2, Yoshihisa Nakahata1, Tristano Pancani1

  • 1Neuronal Signal Transduction Group, Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.

Nature
|October 9, 2024
PubMed
概括

行为时间尺度可塑性 (BTSP) 依赖于延迟的CaMKII激活,而不是直接的突触特异信号. 这种树突,延迟和随机的CaMKII激活在几秒钟内集成神经信号,这对记忆形成至关重要.

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Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
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