在等待名单上的患者和肝移植后不久的患者的身体组成和肌肉组成表型 - 来自试点研究的结果
Mikael F Forsgren1,2,3, Stewart Pine4, Claire Royalle Harrington4
1Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine, Linköping University, Linköping, Sweden.
BMC gastroenterology
|October 9, 2024
概括
磁共振成像 (MRI) 可以评估肝移植 (LT) 患者的身体组成. 在LT后,患者表现出改善的肌肉质量和增加的脂肪组织,这表明MRI.
科学领域:
- 医疗成像医学成像
- 肝病学 肝病学是一种肝病学.
- 移植手术 移植手术
背景情况:
- 在末期肝病中,肉症很普遍,对肝移植 (LT) 结果产生负面影响.
- 磁共振成像 (MRI) 提供了一种评估身体成分和肉症的方法.
研究的目的:
- 评估基于MRI的LT候选人的身体组成概况的可行性.
- 在等待LT的患者中描述身体成分.
- 在等待名单期间和LT之后评估身体成分的变化.
主要方法:
- 潜在的试点研究涉及成年人列为LT.
- 使用8分钟的MRI协议来测量大腿肌肉体积,脂肪透,内脏 (VAT) 和皮下脂肪组织 (ASAT).
- 计算了一个性别和BMI不变的无脂肪肌肉体积z-score (z-FFMV) 和肌肉组成 (MC) 现型.
主要成果:
- 在等待名单上,73%的参与者具有高肌肉脂肪透率 (MFI),39%的参与者表现出不良的肌肉组成 (低z-FFMV,高MFI).
- 在LT后,在200天内观察到z-FFMV (0.22 SDs/30天),VAT (0.23 L/30天) 和ASAT (0.52 L/30天) 的显著增加.
- 在LT后,没有发现MFI或肝脂肪的显著变化.
结论:
- 基于MRI的身体成分分析对LT患者来说是可行的,无论是移植前还是移植后.
- 这种技术可以整合到常规的临床扫描中,以早期识别需要体质干预的患者.
- 在LT之后,身体组成发生了显著的变化,突出显示了监测和管理的必要性.
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