结合IL-22与sCD40L的诊断价值和验证在结核病的多叶膜溢出中
Yuzhen Xu1, Jing Wu1, Qiuju Yao2
1Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Medical College, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, People's Republic of China.
BMC immunology
|October 9, 2024
概括
流中的细胞因子水平可以区分结核性流与恶性流. 干白素-22 (IL-22) 和可溶性CD40连接体 (sCD40L) 在诊断结核性肺炎时具有很高的准确性.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
背景情况:
- 细胞因子与结核病免疫防御有关.
- 从临床上来说,区分结核性肺炎与恶性肺炎是非常重要的.
- 胸腔溢液分析是差异诊断的关键.
研究的目的:
- 为了评估多流中的细胞因子水平,用于差异诊断.
- 为了识别特定的细胞因子,可以区分结核性肺和恶性肺.
- 为了确定关键细胞因子的诊断值.
主要方法:
- 多重细胞因子测定用于测量流中的14种细胞因子.
- 分析包括培训 (n=82) 和验证 (n=76) 队列.
- 接收器操作特征 (ROC) 曲线分析确定了值.
主要成果:
- 所有14种细胞因子在结核性多症中明显高于恶性多症 (P <0.05).
- IL-22,sCD40L,IFN-γ,TNF-α和IL-31显示出高的诊断准确性 (AUC≥0.920). 它们具有较高的诊断准确性.
- 结合IL-22和sCD40L在训练队列中达到94.0%的灵敏度和96.9%的特异性,在验证队列中得到验证.
结论:
- 流中的细胞因子水平升高,使结核性流与恶性流有所区别.
- 针对IL-22 (≥18.87 pg/mL) 和sCD40L (≥53.08 pg/mL) 的特定值提供了一个有效的诊断策略.
- 这种基于细胞因子的方法为临床诊断提供了宝贵的工具.
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