胰岛素耐药性和麻症:中国中老年人中中年龄和老年人中中风风险的预后纵向联系
Canhui Guo1,2, Ling He2, Yansong Tu3
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
BMC public health
|October 9, 2024
概括
胰岛素耐药性和皮症一起显著增加老年人中风风险. 这些疾病的早期发现和治疗对于预防新发性中风至关重要.
科学领域:
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
- 神经学 神经学
背景情况:
- 中风是中国中年和老年人死亡的主要原因.
- 胰岛素耐药性 (IR) 和麻症与代谢性疾病有关,但它们对中风风险的联合影响尚未研究.
- 调查IR,肉症和中风发病率之间的相互作用对公共卫生至关重要.
研究的目的:
- 检查胰岛素耐药性和肉类与中国老年人新发性中风风险之间的关系.
- 为了确定IR和肉症在预测中风风险方面是否独立或协同作用.
- 在老年人群中确定中风预防策略的潜在目标.
主要方法:
- 利用了2011-2018年中国健康与退休纵向研究 (CHARLS) 的纵向数据.
- 采用Cox的比例危险模型来分析IR替代指标和肉病状况与中风发病率之间的关联.
- 包括7009名参与者,其中515人在中位数为7年的随访期间遭受了中风.
主要成果:
- 无论是基线胰岛素抵抗替代品还是肉症,在调整混因素后,都独立预测了中风风险的增加.
- 结合IR (特别是TyG-WC) 和麻症,对中风风险产生了显著的协同效应 (HR: 2.03 [1.52, 2.70]).
- 患有并发症的个人表现出更高的中风风险,IR和肉症的联合存在与不同年龄和性别子组的最高风险有关.
结论:
- 胰岛素耐药性和麻症协同提高了老年人中风的发生率.
- 这些发现为中风检测和干预策略提供了新的见解.
- 强调在老年人群中早期识别和管理IR和肉症的重要性,以减轻中风风险.
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