相关实验视频

Updated: Jun 11, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

美国/PA/MR多式成像导向多功能基因工程生物向协同剂用于瘤治疗

Li Ren^1,2, Yaotai Wang¹, Yu Tang¹

¹State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, 1 Yixueyuan Rd, Yuzhong District, Chongqing, 400016, China.

Journal of nanobiotechnology

|October 10, 2024

概括

这项研究开发了一种使用产生气体的细菌和纳米颗粒的新系统,以加强瘤治疗的聚焦超声波切除手术 (FUAS). 这种方法提高了安全性和有效性,为癌症治疗提供了一个有前途的新策略.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
纳米技术纳米技术

背景情况:

聚焦式超声波切除手术 (FUAS) 是一种微创的瘤治疗方法,其局限性包括安全性,效率和术后残留物.
目前的FUAS缺乏先进的指导,在完全根除瘤方面面临挑战.

研究的目的:

开发一种新的多功能系统,将工程细菌和纳米粒子结合起来,用于增强FUAS.
通过解决现有的临床局限性来提高FUAS的安全性和有效性.

主要方法:

转基因大肠杆菌 (E.coli) 产生气囊 (GVs-E.coli) 用于瘤向和超声波成像.
开发的多功能纳米粒子 (PEI-PLGA/EPI/PFH@Fe3O4) 与超偏磁铁氧化物, perfluorohexane 和 epirubicin 进行协同作用.
使用脉冲聚焦超声波 (PFUS),可调节工作周期以调节热和非热效应.

主要成果:

GVs-E.coli成功准并殖民瘤,促进了超声波成像和PFUS指导.
工程纳米颗粒通过静电吸附在瘤中积累,增强治疗结果.
综合系统证明了协同的瘤根除,改进了传统的FUAS.

结论:

通过GVs-E.coli介导的纳米颗粒与PFUS和化疗协同,以有效治疗瘤.
这种新的方法克服了当前FUAS的局限性,提高了安全性和有效性.
开发的系统为先进的瘤治疗提供了一个有前途的新策略.

关键词:

生物向协同剂生物向协同剂聚焦式超声波除手术.多模式成像技术多模式成像技术脉冲聚焦超声波是指脉冲聚焦的超声波.瘤治疗疗法瘤治疗

更多相关视频

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.