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尿失禁与美国成年人死亡风险之间的关联:前性队列研究
Xuelan Peng1,2, Yingjie Hu1,2, Wenzhi Cai3,4
1Department of Nursing, Shenzhen Hospital, Southern Medical University, Number 1333, Xinhu Road, Baoán District, Shenzhen, Guangdong, 518101, China.
BMC public health
|October 10, 2024
概括
尿失禁 (UI) 与美国成年人死亡风险增加有关. 然而,在调整其他健康因素后,这种关联会减弱,这表明需要进一步研究.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 尿失禁 (UI) 是一种普遍的疾病,影响所有年龄组和性别的人.
- 用户界面给医疗保健系统带来了巨大的,往往被低估的负担.
- UI与死亡风险之间的关系需要进一步研究.
研究的目的:
- 确定尿失禁 (UI) 是否与美国成年人全因,心血管疾病 (CVD) 和癌症死亡率有关.
- 分析UI对死亡率的影响,使用大型,具有全国代表性的数据集.
主要方法:
- 利用了2007-2016年国家健康和营养检查调查 (NHANES) 的数据.
- 包括25182名美国参与者,提供完整的随访和UI信息.
- 采用单变量和多变量考克斯回归分析,UpSet图和卡普兰-梅尔生存曲线.
主要成果:
- 在未调整的模型中,UI与所有原因死亡率增加12% (P=0.008) 和心血管疾病死亡率增加21% (P=0.002) 相联系.
- 在对共变量进行调整后,UI与全因死亡率之间的关联在统计上变得无意义 (下降1%,P=0.868).
- 同样,调整后的癌症死亡率风险也显著下降 (3%,P=0.686).
结论:
- 尿失禁 (UI) 可能作为死亡的独立风险因素.
- 观察到UI与死亡风险之间的关联在调整为混变量后减少.
- 建议对更大的队列和强大的设计进行进一步研究,以澄清UI和死亡率之间的复杂关系.
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