前列腺癌和固体器官移植:患者的治疗和结果
Alon Lazarovich1, Tanya W Kristof1, Shavano Steadman2
1Section of Urology, Department of Surgery, University of Chicago, Chicago, IL, USA.
BJU international
|October 10, 2024
概括
前列腺癌患者可以接受器官移植,因为移植的存在不会显著增加癌症进展的风险. 这一发现支持局部前列腺癌的移植,为改善患者的治疗结果提供希望.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 器官移植,免疫抑制和前列腺癌发病率,进展和死亡率之间的相互作用尚未完全理解.
- 评估移植对前列腺癌的影响对于临床管理和患者咨询至关重要.
研究的目的:
- 分析前列腺癌患者在固体器官移植之前和之后的管理和结果.
- 研究器官移植和免疫抑制对前列腺癌进展和存活率的影响.
主要方法:
- 从两个三级保健中心对110名实体器官移植患者和前列腺癌诊断的回顾性分析.
- 数据收集包括人口统计,临床信息,前列腺癌诊断时间 (移植前或移植后),以及治疗方式.
主要成果:
- 54%的患者接受了移植. 前列腺癌是在62岁的中位年龄被诊断出来的,中位PSA为6.2 ng/mL.
- 41%的人在移植前被诊断出来 (RP 62%,RT 13%,AS 18%);59%的人在移植后被诊断出来 (AS 29%,RT 45%,RP 15%).
- 在随访期间观察到的转移性疾病率低 (移植前2%,移植后5%),并且没有前列腺癌死亡.
结论:
- 局部性前列腺癌不应成为固体器官移植的禁忌.
- 器官移植和免疫抑制似乎不会显著增加前列腺癌进展或死亡的风险.
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