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相关概念视频

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

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A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
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相关实验视频

Updated: Jun 11, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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使用水预和的快速和定量CEST-MRI序列.

Wenxuan Chen1, Zhensen Chen2,3, Lele Ma1

  • 1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.

Magnetic resonance in medicine
|October 10, 2024
PubMed
概括
此摘要是机器生成的。

水预和CEST (WPS CEST) 通过抑制信号污染,显著加快了定量化学交换和转移 (CEST) MRI. 这种新的方法可以通过更短的扫描时间进行准确的量化,改善了体内代谢成像潜力.

关键词:
化学交换和转移 (CEST) 是一种汇率 汇率是指汇率的汇率.定量成像技术 定量成像技术

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相关实验视频

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科学领域:

  • 生物医学工程 生物医学工程
  • 磁共振成像是一种磁共振成像技术.
  • 代谢成像 - 代谢成像

背景情况:

  • 化学交换和转移 (CEST) MRI对体内代谢成像具有前景.
  • 目前的CEST MRI技术受到长时间扫描和由于信号污染而导致不准确的量化限制.
  • 加快CEST成像和改进量化对于其临床和临床前应用至关重要.

研究的目的:

  • 开发一种新的CESTMRI方法,以抑制不同频率之间的信号污染.
  • 为了缩短重复时间 (TR) 以实现更快的CEST成像.
  • 为了能够准确量化CESTMRI中的代谢参数.

主要方法:

  • 开发了一种新的水预和CEST (WPS CEST) 序列,在每个TR开始时包含一个水预和模块.
  • 该模块快速减少了先前TRs的剩余信号,允许磁化重置到零.
  • 在3T时,WPS CEST使用模拟,肌酸幻影和人脑扫描进行了验证.

主要成果:

  • 与传统的CEST相比,WPS CEST可以准确估计汇率 (ksw),延迟时间 (Td) 和和时间 (Ts) 较短.
  • 模拟证实了与WPS CEST在各种Td和Ts之间一致的旋锁放松 (R1ρ) 值.
  • 人类扫描表明,WPS CEST在不同的Td/Ts设置中产生了相同的R1ρ值,而传统的序列显示出显著差异.

结论:

  • 与传统的CEST序列相比,WPS CEST在较短的TR内提供了准确的量化.
  • 这种方法有助于快速定量CEST成像.
  • WPS CEST有潜力显著推进体内代谢成像应用.