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使用水预和的快速和定量CEST-MRI序列
Wenxuan Chen1, Zhensen Chen2,3, Lele Ma1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
Magnetic resonance in medicine
|October 10, 2024
概括
水预和CEST (WPS CEST) 通过抑制信号污染,显著加快了定量化学交换和转移 (CEST) MRI. 这种新的方法可以通过更短的扫描时间进行准确的量化,改善了体内代谢成像潜力.
科学领域:
- 生物医学工程 生物医学工程
- 磁共振成像是一种磁共振成像技术.
- 代谢成像 - 代谢成像
背景情况:
- 化学交换和转移 (CEST) MRI对体内代谢成像具有前景.
- 目前的CEST MRI技术受到长时间扫描和由于信号污染而导致不准确的量化限制.
- 加快CEST成像和改进量化对于其临床和临床前应用至关重要.
研究的目的:
- 开发一种新的CESTMRI方法,以抑制不同频率之间的信号污染.
- 为了缩短重复时间 (TR) 以实现更快的CEST成像.
- 为了能够准确量化CESTMRI中的代谢参数.
主要方法:
- 开发了一种新的水预和CEST (WPS CEST) 序列,在每个TR开始时包含一个水预和模块.
- 该模块快速减少了先前TRs的剩余信号,允许磁化重置到零.
- 在3T时,WPS CEST使用模拟,肌酸幻影和人脑扫描进行了验证.
主要成果:
- 与传统的CEST相比,WPS CEST可以准确估计汇率 (ksw),延迟时间 (Td) 和和时间 (Ts) 较短.
- 模拟证实了与WPS CEST在各种Td和Ts之间一致的旋锁放松 (R1ρ) 值.
- 人类扫描表明,WPS CEST在不同的Td/Ts设置中产生了相同的R1ρ值,而传统的序列显示出显著差异.
结论:
- 与传统的CEST序列相比,WPS CEST在较短的TR内提供了准确的量化.
- 这种方法有助于快速定量CEST成像.
- WPS CEST有潜力显著推进体内代谢成像应用.
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