相关实验视频
Updated: Jun 11, 2025
05:17
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
112
根据非阿尔茨海默氏病痴呆症中的粉样蛋白阳性,不同的认知轨迹
Hyemin Jang, Min Young Chun, Jihwan Yun
1From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Clinical nuclear medicine
|October 10, 2024
概括
β-粉样蛋白阳性 (Aβ+) 在患有皮下血管认知障碍 (SVCI) 的老年人中更常见,并且与SVCI的认知衰退更快相关,但不是前性痴呆症 (FTD).
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
背景情况:
- β-粉样蛋白阳性 (Aβ+) 对痴呆症共病理学的临床影响尚未研究.
- 皮下血管认知障碍 (SVCI) 和前性痴呆症 (FTD) 是不同的神经退行性疾病.
- 了解Aβ+患病率和影响对于诊断和管理痴呆症至关重要.
研究的目的:
- 为了调查Aβ+在SVCI和FTD患者中的患病率.
- 检查Aβ+对SVCI和FTD认知轨迹的临床影响.
- 为了比较跨诊断群体和人口统计因素的Aβ+患病率.
主要方法:
- 招募了583名SVCI,152名FTD和1,249名认知正常 (CU) 参与者.
- 使用AβPET扫描来评估β-粉样蛋白的阳性.
- 使用后勤回归和线性混合效应模型来分析Aβ+患病率和认知变化.
主要成果:
- 与CU患者相比,75-90岁的SVCI患者的Aβ+患病率较高 (aOR=1.97).
- 在具有APOE ε3/ε3基因型 (aOR=1.78) 的SVCI患者中,Aβ+的发病率更高.
- 在SVCI中,Aβ+与认知轨迹的恶化有关 (β=-0.6424),但在FTD中并非如此.
结论:
- 在老年SVCI患者中,Aβ+更为普遍,并且与加速的认知衰退有关.
- 与对照组相比,FTD患者的Aβ+患病率没有不同.
- 这些发现提高了对韩国不同类型痴呆症Aβ生物标志物特征的理解.
相关概念视频
01:26Alzheimer's Disease: Overview
449
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
449
01:30Dementia
97
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
97
01:30Cognitive Development During Adulthood
65
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
65
01:22Alzheimer's Disease: Treatment
166
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
166
03:03Amyloid Fibrils
5.1K
5.1K
01:03Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K