相关实验视频

Updated: Jun 11, 2025

In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue

In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue

Published on: July 6, 2017

语言神经电刺激对 Xerostomia 的影响:一个随机对照试验

K Xu¹, S Ma¹, S Jia²

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

JDR clinical and translational research

|October 10, 2024

概括

语言神经的电刺激显著改善了异口症患者的口腔干燥症状和唾液流量. 这种非药理学方法为治疗口腔干燥提供了一个有希望的替代方案.

科学领域:

神经学神经学
口腔医学是指口腔医学.
生物医学工程生物医学工程

背景情况:

乾口症 (xerostomia) 影响全球数以百万计的人口,目前的治疗方法往往会引起副作用.
现有的异口症管理策略存在局限性,需要新的治疗方法.

研究的目的:

为了研究电刺激语言神经作为治疗异口症的疗效.
评估语言神经电刺激对异口症症状严重程度和唾液功能的影响.

主要方法:

这是一项随机对照试验,比较了12周的语言神经电刺激与假手术.
参与者 (n=47) 用视觉模拟尺度对异口,唾液流量 (刺激/不刺激) 和口腔健康影响概况-14 (OHIP-14) 进行评估.

主要成果:

与假的相比,电刺激显著降低了异口症得分 (平均差异为13.8).
在治疗组中观察到更高的缓解率 (61.9%与28.6%) 和非刺激的唾液流量增加 (平均差异为14.5μL/分钟).
用电刺激观察到口腔生活质量的显著改善 (OHIP-14评分),而刺激的唾液流没有显著差异.

结论:

语言神经的电刺激是一种有前途的非侵入性,非药物治疗异口症.
这种模式显示出改善患者报告结果和口腔干燥患者的唾液功能的潜力.
需要进一步的研究来探索语言神经电刺激的长期有效性和最佳参数.

关键词:

电刺激是一种电刺激.神经生物学神经生物学神经生物学神经生理学神经生理学人们的生活质量.唾液腺体唾液腺体唾液腺体视觉模拟尺度是一个视觉模拟尺度.

更多相关视频

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation

Published on: May 4, 2018

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

Published on: May 17, 2019

相关概念视频

Salivary Glands and Saliva

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...

Drugs Acting on Autonomic Ganglia: Stimulants

Drugs Acting on Autonomic Ganglia: Stimulants

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...