125年阿司匹林:分析方法的现状
Natalia Sabina Dos Santos Galvao1, Aline Sinzervinch1, Isadora Alves Lustosa1
1Department of Pharmacy, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.
Current pharmaceutical design
|October 10, 2024
概括
为了庆祝阿司匹林 (乙撒利酸) 125 周年,本文审查了其制药品的分析方法. 目前的方法,主要是HPLC和UV-vis,缺乏生态效率,突出需要更绿色的分析化学方法.
科学领域:
- 药品分析 药品分析
- 绿色化学 绿色化学
- 药品质量控制 药品质量控制
背景情况:
- 阿司匹林 (乙盐酸) 是一种广泛使用的止痛药,抗发烧药和抗炎药,具有125年的历史.
- 尽管它在市场上长期存在,并且在新应用和组合方面不断创新,但其质量控制的分析方法并没有显著发展.
研究的目的:
- 为了回顾和庆祝阿司匹林 (乙盐酸) 在制药市场的125年.
- 评估用于含有乙酸 (ASA) 的药品的分析方法的现状.
- 将这些方法置于绿色和清洁分析化学的原则中.
主要方法:
- 对乙酸 (ASA) 评估分析方法的文献综述.
- 分析主要使用的技术 (HPLC,UV-vis) 和溶剂 (甲醇,乙二,缓冲剂).
- 检查常见的药物矩阵 (药片,组合药物).
主要成果:
- 高性能液体染色学 (HPLC) 和紫外可见光谱法 (UV-vis) 是ASA分析的最常见方法 (分别为41%).
- 在这些分析方法中,甲醇和乙二是普遍存在的有机溶剂.
- 最常被分析的药物形式是ASA片,其次是组合产品.
结论:
- 目前基于乙酸 (ASA) 的药品分析方法与绿色和可持续化学原则不一致.
- 有一个重要的机会来提高分析方法的生态效率,以满足现代需求.
- 阿司匹林应用的创新与其质量控制分析方法的停滞形成鲜明对比.
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