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可注射的水凝加载大麻可调节巨细胞两极分化在体外治疗慢性肠炎的治疗
Ye Wang1,2, Xingming Ji2,3, Xinyi Wang2
1Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang Province, China.
Journal of applied biomaterials & functional materials
|October 10, 2024
概括
这项研究开发了一种含大麻素 (CBD) 的水凝系统 (GelMA+CBD),用于慢性肠病. 水凝显示生物安全性,缓慢CBD释放,并有效地减少炎症和氧化应激在体外.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性肠道疾病是一种普遍的疾病,其特点是高复发率和炎症.
- 大麻二醇 (CBD) 具有抗炎和抗氧化特性,但其生物可用性较差.
- 开发有效的药物输送系统对于管理慢性炎症疾病至关重要.
研究的目的:
- 准备和描述一种新的水凝系统 (GelMA+CBD),用于持续地在现场输送大麻素 (CBD).
- 为了在体外评估含有CBD的水凝系统的抗炎和抗氧化疗效.
- 评估GelMA+CBD作为慢性炎症性肠病治疗策略的潜力.
主要方法:
- 使用扫描电子显微镜制造和表征GelMA+CBD水凝系统.
- 评估水凝膨胀率,毛孔大小和药物释放动力学.
- 通过使用ELISA和激光共焦显微镜测量巨细胞两极分化,炎症因子表达 (iNOS,Arg-1) 和反应性氧物种 (ROS) 水平来对抗炎症作用的体外评估.
主要成果:
- 凝MA+CBD水凝系统表现出良好的生物安全性和持续释放的CBD.
- 实验室研究表明,GelMA+CBD有效抑制了促炎性M1巨细胞两极分化,并促进了抗炎性M2两极分化.
- 该系统显著降低了促炎因素 (iNOS),增加了抗炎因素 (Arg-1),并清除了细胞内ROS,减轻了氧化应激.
结论:
- 开发的CBD装载水凝系统 (GelMA+CBD) 是安全有效的,用于体外治疗慢性炎症.
- 水凝调节了巨细胞的两极分化,减少了促炎因素的分泌,减轻了氧化应激.
- 这项研究为使用GelMA+CBD水凝治疗慢性肠炎提供了坚实的基础.
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